Economic Impact of Oral Therapies for Chronic Lymphocytic Leukemia—the Burden of Novelty

Talal Hilal, Jeffrey A. Betcher, Jose F. Leis

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Purpose of Review: Small molecule tyrosine kinase inhibitors (TKIs) and BCL2 inhibitors are oral targeted therapies that have changed the treatment approach to patients with chronic lymphocytic leukemia (CLL). The aim of this review is to summarize the relevant literature on the economic impact of oral novel therapies for the treatment of CLL and discuss the underlying factors and suggested solutions for high drug prices. Recent Findings: The cost of therapy for CLL has increased substantially since the introduction of oral therapies. This increase in cost is caused by multiple factors including cost of drug development, alternate reimbursement patterns, lack of transparency, and lack of free market competition. Summary: Oral therapies for CLL have dramatically increased costs for both patients and payers. Some solutions to overcome this include value-based pricing, transparency, and legal action that allow Medicare to negotiate drug prices with manufacturers.

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalCurrent Hematologic Malignancy Reports
Issue number4
StatePublished - Aug 1 2018


  • CLL
  • Drug costs
  • Ibrutinib
  • Idelalisib
  • Pharmacoeconomics, financial toxicity
  • Venetoclax

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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