Abstract
Recent data suggest that oral therapy can be effective for bone infections. We aim to assess the efficacy of an early switch to oral therapy (<2 weeks) compared to a non-early switch in bacterial native vertebral osteomyelitis. We conducted a cohort study at Mayo Clinic, Rochester (MN), between 2019-2021 combined with a systematic review, which queried multiple databases. Data were analyzed using a random-effects model. The cohort study included 139 patients: two received an early switch. Of 3708 citations, 13 studies were included in the final analysis. Meta-analysis demonstrated no difference in treatment failure (odds ratio=1.073, 95-0.370-3.116), but many studies presented high risk of bias. Current evidence is insufficient to conclude the proportion of patients with failure or relapse is different in the two groups. High-quality studies are warranted before early switch can be routinely recommended.
Original language | English (US) |
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Pages (from-to) | 249-257 |
Number of pages | 9 |
Journal | Journal of Bone and Joint Infection |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Nov 23 2022 |
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
- Infectious Diseases