Early skin immunological disturbance after Plasmodium-infected mosquito bites

Henrique Borges da Silva, Susana S. Caetano, Isadora Monteiro, Iván Gómez-Conde, Kirsten Hanson, Carlos Penha-Gonçalves, David N. Olivieri, Maria M. Mota, Cláudio R. Marinho, Maria R. D'Imperio Lima, Carlos E. Tadokoro

Research output: Contribution to journalArticlepeer-review


Although the role of regulatory T cells (Tregs) during malaria infection has been studied extensively, such studies have focused exclusively on the role of Treg during the blood stage of infection; little is known about the detailed mechanisms of Tregs and sporozoite deposition in the dermis by mosquito bites. In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobility of skin Tregs and dendritic cells (DCs). We also show differences in MHC class II and/or CD86 expression on skin-resident dendritic cell subtypes and macrophages. From the observed decrease of the number of APCs into draining lymph nodes, suppression of CD28 expression in conventional CD4 T cells, and a low homeostatic proliferation of skin-migrated CD4 T found in nude mice indicate that Tregs may play a fundamental role during the initial phase of malaria parasite inoculation into the mammalian host.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalCellular Immunology
Issue number1-2
StatePublished - May 2012


  • Dendritic cell
  • Immunity
  • Plasmodium berghei
  • Regulatory T cell
  • Skin

ASJC Scopus subject areas

  • Immunology


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