Early Right Ventricular Reverse Remodeling Predicts Survival After Isolated Tricuspid Valve Surgery

Sri Harsha Patlolla, Hartzell V. Schaff, Kevin L. Greason, Alberto Pochettino, Richard C. Daly, Robert L. Frye, Rick A. Nishimura, Joseph A. Dearani

Research output: Contribution to journalArticlepeer-review


Background: There are limited data on the impact of isolated tricuspid valve (TV) surgery on recovery of right ventricular (RV) function and RV reverse remodeling. Methods: Among 223 patients who had isolated TV procedures between 2001 and 2017, 60 (27%) underwent TV repair and 163 (73%) received TV replacement. Indication for surgery was functional tricuspid valve regurgitation in 64%, lead induced in 18%, and primary leaflet dysfunction in 18%. RV reverse remodeling was assessed by echocardiography at a median of 11.3 months (interquartile range [IQR] 5.9-13.5) post-dismissal. Results: Mean age was 67.3 ± 13.7 years, and 57% were female. Overall 30-day mortality was 2.7%. After a median follow-up period of 9.5 years (IQR 3.6-12.9), adjusted Cox regression analysis revealed comparable survival for TV repair and replacement and identified older age, and presence of RV dysfunction (hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.14-2.98; P =.01), as independent predictors of poor survival. Patients who exhibited RV reverse remodeling within 18 months postoperatively had significantly improved survival compared with those who did not (log-rank P =.005), and reverse remodeling was independently associated with improved survival (HR 0.42, 95% CI 0.24-0.74; P =.003). Lower preoperative right atrial pressure (odds ratio 0.83, 95% CI 0.73-0.94; P =.004) was predictive of early RV reverse remodeling. Conclusions: Isolated TV surgery can be performed with acceptable outcomes (early mortality 2.7%), and overall survival is best in patients who receive the operation before developing RV systolic dysfunction. Adjusted survival was similar for patients undergoing TV repair or replacement. Early reverse remodeling of RV after surgery is associated with survival benefit.

Original languageEnglish (US)
Pages (from-to)1402-1409
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - Nov 2021

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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