Early diagnosis and treatment of rejection in pancreas transplantation

A major reason for failure in pancreas transplantation is the difficulty in making an early diagnosis of graft rejection so that it can be treated effectively. A rise in plasma glucose concentration occurs late in the course of rejection and by that time usually most of the islet mass has been destroyed and antirejection therapy cannot reverse the process. With urinary diversion of the pancreatic secretions, we have the possibility of monitoring the exocrine secretion. The goal of this study was to try to detect and reverse effectively rejection before the onset of hyperglycemia.