TY - JOUR
T1 - Dysregulation of c-myc in multiple myeloma
AU - Kuehl, W. M.
AU - Brents, L. A.
AU - Chesi, M.
AU - Huppi, K.
AU - Bergsagel, P. L.
PY - 1997
Y1 - 1997
N2 - Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism.
AB - Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism.
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U2 - 10.1007/978-3-642-60801-8_29
DO - 10.1007/978-3-642-60801-8_29
M3 - Article
C2 - 9308252
AN - SCOPUS:0030623503
SN - 0070-217X
VL - 224
SP - 279
EP - 282
JO - Current topics in microbiology and immunology
JF - Current topics in microbiology and immunology
ER -