TY - JOUR
T1 - Dual Primary IGH Translocations in Multiple Myeloma
T2 - A Novel Finding
AU - Ravindran, Aishwarya
AU - Greipp, Patricia T.
AU - Wongchaowart, Nicholas
AU - Smadbeck, James B.
AU - Peterson, Jess F.
AU - Ketterling, Rhett P.
AU - Kumar, Shaji K.
AU - Baughn, Linda B.
N1 - Funding Information:
The authors thank the cytotechnologists (Sara M. Kloft-Nelson, Ryan A. Knudson, and Troy J. Gliem) at the Mayo Clinic Cytogenetics Core, Medical Genome Facility, who assisted in performing the FISH studies relevant to this study. The Cytogenetics Core is supported by the Mayo Clinic Comprehensive Cancer Center Grant (P30CA15083).
Publisher Copyright:
© 2021
PY - 2021/9
Y1 - 2021/9
N2 - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).
AB - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).
KW - Clonal Cytogenetic Abnormality
KW - Cytogenetics Risk Stratification
KW - Immunoglobulin heavy chain
KW - Plasma Cell Neoplasm
KW - Plasma Cell-Specific FISH
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U2 - 10.1016/j.clml.2021.05.001
DO - 10.1016/j.clml.2021.05.001
M3 - Article
C2 - 34172422
AN - SCOPUS:85108582171
SN - 2152-2650
VL - 21
SP - e710-e713
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 9
ER -