Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding

Aishwarya Ravindran, Patricia T. Greipp, Nicholas Wongchaowart, James B. Smadbeck, Jess F. Peterson, Rhett P. Ketterling, Shaji K. Kumar, Linda B. Baughn

Research output: Contribution to journalArticlepeer-review


• Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).

Original languageEnglish (US)
Pages (from-to)e710-e713
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number9
StatePublished - Sep 2021


  • Clonal Cytogenetic Abnormality
  • Cytogenetics Risk Stratification
  • Immunoglobulin heavy chain
  • Plasma Cell Neoplasm
  • Plasma Cell-Specific FISH

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


Dive into the research topics of 'Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding'. Together they form a unique fingerprint.

Cite this