Dravet Syndrome as an Example of Precision Medicine in Epilepsy

Joseph Sullivan; Elaine C. Wirrell

doi:10.1177/15357597221106281

Dravet Syndrome as an Example of Precision Medicine in Epilepsy

Joseph Sullivan, Elaine C. Wirrell

Neurology

Research output: Contribution to journal › Review article › peer-review

Abstract

Dravet syndrome (DS) is a drug-resistant, early-onset, developmental and epileptic encephalopathy where there have been many recently approved therapies with many more in development. With the availability of more syndrome specific treatment options coupled with an earlier diagnosis, DS is well-positioned to be an example of how a precise syndromic diagnosis can guide treatment choices and improve overall outcomes and also allow for the development of potential disease modifying therapies to address more than just seizures. In this review we summarize the current state of DS approved therapies and those that are in various stages of development.

Original language	English (US)
Pages (from-to)	4-7
Number of pages	4
Journal	Epilepsy Currents
Volume	23
Issue number	1
DOIs	https://doi.org/10.1177/15357597221106281
State	Published - Jan 1 2023

Keywords

Dravet
anti seizure medication
developmental epileptic encephalopathy
disease modifying therapy
epilepsy syndrome
precision medicine

ASJC Scopus subject areas

Clinical Neurology

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AB - Dravet syndrome (DS) is a drug-resistant, early-onset, developmental and epileptic encephalopathy where there have been many recently approved therapies with many more in development. With the availability of more syndrome specific treatment options coupled with an earlier diagnosis, DS is well-positioned to be an example of how a precise syndromic diagnosis can guide treatment choices and improve overall outcomes and also allow for the development of potential disease modifying therapies to address more than just seizures. In this review we summarize the current state of DS approved therapies and those that are in various stages of development.

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Dravet Syndrome as an Example of Precision Medicine in Epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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