Does aging adversely affect muscle mitochondrial function?

Kevin R. Short, K. Sreekumaran Nair

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalExercise and sport sciences reviews
Issue number3
StatePublished - Jul 2001


  • Cytochrome c oxidase
  • MRNA
  • MtDNA
  • Oxidative damage
  • Oxidative phosphorylation
  • Protein synthesis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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