Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: Preliminary results

Georg Gahn; Robert H. Ackerman; Morelia R. Candia; Kevin M. Barrett; Michael H. Lev; Agnes Y. Huang

doi:10.7863/jum.1999.18.2.101

Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: Preliminary results

Georg Gahn, Robert H. Ackerman, Morelia R. Candia, Kevin M. Barrett, Michael H. Lev, Agnes Y. Huang

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To assess the efficacy in carotid diagnosis of an investigational dodecafluoropentane ultrasonic contrast enhancing agent, we compared B-mode, color flow, and duplex Doppler findings in 16 patients with common carotid artery bifurcation disease after dodecafluoropentane and saline injections. Dodecafluoropentane produced enhanced backscatter in all patients for 4 to 20 min (mean, 8.4±4.74 min) after intravenous injection. In six patients this enhancement improved the color flow and pulsed Doppler signal detection in areas of sonographic shadowing. The enhanced color flow information changed the diagnostic impression in one case. Dodecafluoropentane produced enhanced backscatter in the carotid artery in all patients, and for a mean duration longer than that reported for other agents. It has the potential to improve the efficacy of carotid ultrasonic evaluation.

Original language	English (US)
Pages (from-to)	101-108
Number of pages	8
Journal	Journal of Ultrasound in Medicine
Volume	18
Issue number	2
DOIs	https://doi.org/10.7863/jum.1999.18.2.101
State	Published - Jan 1 1999

Keywords

Carotid stenosis
Contrast media
Neurovascular evaluation
Spiral computed tomograpic angiography
Ultrasonography

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.7863/jum.1999.18.2.101

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title = "Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: Preliminary results",

abstract = "To assess the efficacy in carotid diagnosis of an investigational dodecafluoropentane ultrasonic contrast enhancing agent, we compared B-mode, color flow, and duplex Doppler findings in 16 patients with common carotid artery bifurcation disease after dodecafluoropentane and saline injections. Dodecafluoropentane produced enhanced backscatter in all patients for 4 to 20 min (mean, 8.4±4.74 min) after intravenous injection. In six patients this enhancement improved the color flow and pulsed Doppler signal detection in areas of sonographic shadowing. The enhanced color flow information changed the diagnostic impression in one case. Dodecafluoropentane produced enhanced backscatter in the carotid artery in all patients, and for a mean duration longer than that reported for other agents. It has the potential to improve the efficacy of carotid ultrasonic evaluation.",

keywords = "Carotid stenosis, Contrast media, Neurovascular evaluation, Spiral computed tomograpic angiography, Ultrasonography",

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AU - Gahn, Georg

AU - Ackerman, Robert H.

AU - Candia, Morelia R.

AU - Barrett, Kevin M.

AU - Lev, Michael H.

AU - Huang, Agnes Y.

PY - 1999/1/1

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AB - To assess the efficacy in carotid diagnosis of an investigational dodecafluoropentane ultrasonic contrast enhancing agent, we compared B-mode, color flow, and duplex Doppler findings in 16 patients with common carotid artery bifurcation disease after dodecafluoropentane and saline injections. Dodecafluoropentane produced enhanced backscatter in all patients for 4 to 20 min (mean, 8.4±4.74 min) after intravenous injection. In six patients this enhancement improved the color flow and pulsed Doppler signal detection in areas of sonographic shadowing. The enhanced color flow information changed the diagnostic impression in one case. Dodecafluoropentane produced enhanced backscatter in the carotid artery in all patients, and for a mean duration longer than that reported for other agents. It has the potential to improve the efficacy of carotid ultrasonic evaluation.

KW - Carotid stenosis

KW - Contrast media

KW - Neurovascular evaluation

KW - Spiral computed tomograpic angiography

KW - Ultrasonography

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Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: Preliminary results

Abstract

Keywords

ASJC Scopus subject areas

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