Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: Preliminary results

Georg Gahn, Robert H. Ackerman, Morelia R. Candia, Kevin M. Barrett, Michael H. Lev, Agnes Y. Huang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


To assess the efficacy in carotid diagnosis of an investigational dodecafluoropentane ultrasonic contrast enhancing agent, we compared B-mode, color flow, and duplex Doppler findings in 16 patients with common carotid artery bifurcation disease after dodecafluoropentane and saline injections. Dodecafluoropentane produced enhanced backscatter in all patients for 4 to 20 min (mean, 8.4±4.74 min) after intravenous injection. In six patients this enhancement improved the color flow and pulsed Doppler signal detection in areas of sonographic shadowing. The enhanced color flow information changed the diagnostic impression in one case. Dodecafluoropentane produced enhanced backscatter in the carotid artery in all patients, and for a mean duration longer than that reported for other agents. It has the potential to improve the efficacy of carotid ultrasonic evaluation.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number2
StatePublished - Jan 1 1999


  • Carotid stenosis
  • Contrast media
  • Neurovascular evaluation
  • Spiral computed tomograpic angiography
  • Ultrasonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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