TY - JOUR
T1 - Do patients with nonmetastatic non-small cell lung cancer demonstrate altered resting energy expenditure?
AU - Jatoi, Aminah
AU - Daly, Benedict D.T.
AU - Hughes, Virginia A.
AU - Dallal, Gerard E.
AU - Kehayias, Joseph
AU - Roubenoff, Ronenn
N1 - Funding Information:
This work was supported by grants F32CA69742 (AJ) and M01RR00054-36A1 from the National Institutes of Health and USDA contract 53-3K06-5-10.
PY - 2001/8
Y1 - 2001/8
N2 - Background. The cancer cachexia syndrome occurs in patients with non-small cell lung cancer (NSCLC) and includes elevated resting energy expenditure (REE). This increase in REE leads to weight loss, which in turn confers a poor prognosis. This study was undertaken to determine whether the cancer cachexia syndrome occurs in patients with nonmetastatic NSCLC. Methods. In this case-control study, 18 patients with nonmetastatic NSCLC (stages IA to IIIB) were matched to healthy controls on age (± 5 years), gender, and body mass index (± 3 kg/m2). Only 4 cancer patients had experienced > 5% weight loss. Cancer patients and controls were compared on the basis of: (1) unadjusted REE, as measured by indirect calorimetry; (2) REE adjusted for lean body mass, as measured by dual x-ray absorptiometry; (3) REE adjusted for body cell mass, as measured by potassium-40 measurement; and (4) REE adjusted for total body water, as measured by tritiated water dilution. Results. We observed no significant difference in unadjusted REE or in REE adjusted for total body water. However, with separate adjustments for lean body mass and body cell mass, cancer patients manifested an increase in REE: mean difference ± standard error of the mean: 140 ± 35 kcal/day (p = 0.001) and 173 ± 65 kcal/day (p = 0.032), respectively. Further adjustment for weight loss yielded similarly significant results. Conclusions. These results suggest that the cancer cachexia syndrome occurs in patients with nonmetastatic NSCLC and raise the question of whether clinical trials that target cancer cachexia should be initiated before weight loss.
AB - Background. The cancer cachexia syndrome occurs in patients with non-small cell lung cancer (NSCLC) and includes elevated resting energy expenditure (REE). This increase in REE leads to weight loss, which in turn confers a poor prognosis. This study was undertaken to determine whether the cancer cachexia syndrome occurs in patients with nonmetastatic NSCLC. Methods. In this case-control study, 18 patients with nonmetastatic NSCLC (stages IA to IIIB) were matched to healthy controls on age (± 5 years), gender, and body mass index (± 3 kg/m2). Only 4 cancer patients had experienced > 5% weight loss. Cancer patients and controls were compared on the basis of: (1) unadjusted REE, as measured by indirect calorimetry; (2) REE adjusted for lean body mass, as measured by dual x-ray absorptiometry; (3) REE adjusted for body cell mass, as measured by potassium-40 measurement; and (4) REE adjusted for total body water, as measured by tritiated water dilution. Results. We observed no significant difference in unadjusted REE or in REE adjusted for total body water. However, with separate adjustments for lean body mass and body cell mass, cancer patients manifested an increase in REE: mean difference ± standard error of the mean: 140 ± 35 kcal/day (p = 0.001) and 173 ± 65 kcal/day (p = 0.032), respectively. Further adjustment for weight loss yielded similarly significant results. Conclusions. These results suggest that the cancer cachexia syndrome occurs in patients with nonmetastatic NSCLC and raise the question of whether clinical trials that target cancer cachexia should be initiated before weight loss.
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U2 - 10.1016/S0003-4975(01)02847-8
DO - 10.1016/S0003-4975(01)02847-8
M3 - Article
C2 - 11515864
AN - SCOPUS:0034904166
SN - 0003-4975
VL - 72
SP - 348
EP - 351
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 2
ER -