DNMT1 knockout delivers a strong blow to genome stability and cell viability

Kevin D. Brown; Keith D. Robertson

doi:10.1038/ng0307-289

DNMT1 knockout delivers a strong blow to genome stability and cell viability

Kevin D. Brown, Keith D. Robertson

Pharmacology

Research output: Contribution to journal › Short survey › peer-review

40 Scopus citations

Abstract

The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

Original language	English (US)
Pages (from-to)	289-290
Number of pages	2
Journal	Nature Genetics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1038/ng0307-289
State	Published - Mar 2007

ASJC Scopus subject areas

Genetics

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10.1038/ng0307-289

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DNMT1 knockout delivers a strong blow to genome stability and cell viability

Abstract

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