DNA topoisomerase IIα (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: In vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes

Medicine & Life Sciences

• Topoisomerase II Inhibitors 100%
• erbB-2 Genes 97%
• Fatty Acid Synthases 92%
• Up-Regulation 50%
• Breast Neoplasms 44%
• Gene Expression 42%
• In Vitro Techniques 30%
• Genes 28%
• Type II DNA Topoisomerase 10%
• Transcriptional Activation 7%
• Sterol Regulatory Element Binding Proteins 6%
• Pharmaceutical Preparations 5%
• Trastuzumab 4%
• Drug Therapy 4%
• Vincristine 4%
• Etoposide 4%
• Paclitaxel 4%
• DNA Replication 4%
• Protein Binding 4%
• S Phase 4%
• Microtubules 4%
• Fluorouracil 3%
• Oncogenes 3%
• Doxorubicin 3%
• Cisplatin 3%
• Epigenomics 3%
• Fatty Acids 3%
• Cultured Cells 3%
• Binding Sites 3%
• Maintenance 2%
• Neoplasms 2%
• Phenotype 2%
• Antibodies 2%
• Enzymes 2%
• Proteins 1%
• Therapeutics 0%