DNA methylation, age-related immune defects, and autoimmunity

Jörg J. Goronzy; Guangjin Li; Cornelia M. Weyand

doi:10.1007/978-1-4419-0639-7_18

DNA methylation, age-related immune defects, and autoimmunity

Jörg J. Goronzy, Guangjin Li, Cornelia M. Weyand

Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The adaptive immune system is a highly proliferative organ that combines ongoing differentiation with preservation of memory. CpG DNA methylation is central to many of the fate decisions that occur from early lymphoid development to late effector functions of end-differentiated cells. Many of the DNA demethylation-sensitive genes play an important role in autoimmune diseases and in the immune defects that are associated with the aging process, suggesting that failing epigenetic control mechanisms of genes involved in adaptive immune responses contribute to these diseases.

Original language	English (US)
Title of host publication	Epigenetics of Aging
Publisher	Springer New York
Pages	327-344
Number of pages	18
ISBN (Electronic)	9781441906397
ISBN (Print)	9781441906380
DOIs	https://doi.org/10.1007/978-1-4419-0639-7_18
State	Published - 2010

Keywords

Aging
Epigenetics
Immune senescence
T cells

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4419-0639-7_18

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AB - The adaptive immune system is a highly proliferative organ that combines ongoing differentiation with preservation of memory. CpG DNA methylation is central to many of the fate decisions that occur from early lymphoid development to late effector functions of end-differentiated cells. Many of the DNA demethylation-sensitive genes play an important role in autoimmune diseases and in the immune defects that are associated with the aging process, suggesting that failing epigenetic control mechanisms of genes involved in adaptive immune responses contribute to these diseases.

KW - Aging

KW - Epigenetics

KW - Immune senescence

KW - T cells

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ER -

DNA methylation, age-related immune defects, and autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

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