Dissecting molecular mechanisms in bile acid diarrhea

Michael Camilleri

doi:10.1038/ajg.2016.23

Dissecting molecular mechanisms in bile acid diarrhea

Michael Camilleri

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone - fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and 75 SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with 75 SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.

Original language	English (US)
Pages (from-to)	433-435
Number of pages	3
Journal	American Journal of Gastroenterology
Volume	111
Issue number	3
DOIs	https://doi.org/10.1038/ajg.2016.23
State	Published - Mar 1 2016

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1038/ajg.2016.23

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title = "Dissecting molecular mechanisms in bile acid diarrhea",

abstract = "It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone - fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and 75 SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with 75 SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.",

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AB - It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone - fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and 75 SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with 75 SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.

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Dissecting molecular mechanisms in bile acid diarrhea

Abstract

ASJC Scopus subject areas

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