TY - JOUR
T1 - Disrupted thalamocortical connectivity in PSP
T2 - A resting-state fMRI, DTI, and VBM study
AU - Whitwell, Jennifer L.
AU - Avula, Ramesh
AU - Master, Ankit
AU - Vemuri, Prashanthi
AU - Senjem, Matthew L.
AU - Jones, David T.
AU - Jack, Clifford R.
AU - Josephs, Keith A.
N1 - Funding Information:
This work was supported by the Dana Foundation ; National Institutes of Health (grant numbers R01-DC010367 , R01-AG037491 , R21-AG38736 , and R01-AG11378 ) and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation. We would like to acknowledge Drs. Scott Eggers, J. Eric Ahlskog and Joseph Matsumoto for referring patients for this study.
PY - 2011/9
Y1 - 2011/9
N2 - Progressive supranuclear palsy (PSP) is associated with pathological changes along the dentatorubrothalamic tract and in premotor cortex. We aimed to assess whether functional neural connectivity is disrupted along this pathway in PSP, and to determine how functional changes relate to changes in structure and diffusion. Eighteen probable PSP subjects and 18 controls had resting-state (task-free) fMRI, diffusion tensor imaging and structural MRI. Functional connectivity was assessed between thalamus and the rest of the brain, and within the basal ganglia, salience and default mode networks (DMN). Patterns of atrophy were assessed using voxel-based morphometry, and patterns of white matter tract degeneration were assessed using tract-based spatial statistics. Reduced in-phase functional connectivity was observed between the thalamus and premotor cortex including supplemental motor area (SMA), striatum, thalamus and cerebellum in PSP. Reduced connectivity in premotor cortex, striatum and thalamus were observed in the basal ganglia network and DMN, with subcortical salience network reductions. Tract degeneration was observed between cerebellum and thalamus and in superior longitudinal fasciculus, with grey matter loss in frontal lobe, premotor cortex, SMA and caudate nucleus. SMA functional connectivity correlated with SMA volume and measures of cognitive and motor dysfunction, while thalamic connectivity correlated with degeneration of superior cerebellar peduncles. PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy.
AB - Progressive supranuclear palsy (PSP) is associated with pathological changes along the dentatorubrothalamic tract and in premotor cortex. We aimed to assess whether functional neural connectivity is disrupted along this pathway in PSP, and to determine how functional changes relate to changes in structure and diffusion. Eighteen probable PSP subjects and 18 controls had resting-state (task-free) fMRI, diffusion tensor imaging and structural MRI. Functional connectivity was assessed between thalamus and the rest of the brain, and within the basal ganglia, salience and default mode networks (DMN). Patterns of atrophy were assessed using voxel-based morphometry, and patterns of white matter tract degeneration were assessed using tract-based spatial statistics. Reduced in-phase functional connectivity was observed between the thalamus and premotor cortex including supplemental motor area (SMA), striatum, thalamus and cerebellum in PSP. Reduced connectivity in premotor cortex, striatum and thalamus were observed in the basal ganglia network and DMN, with subcortical salience network reductions. Tract degeneration was observed between cerebellum and thalamus and in superior longitudinal fasciculus, with grey matter loss in frontal lobe, premotor cortex, SMA and caudate nucleus. SMA functional connectivity correlated with SMA volume and measures of cognitive and motor dysfunction, while thalamic connectivity correlated with degeneration of superior cerebellar peduncles. PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy.
KW - Atrophy
KW - Dentatorubrothalamic tract
KW - Functional connectivity
KW - Resting-state fMRI
KW - White matter tracts
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U2 - 10.1016/j.parkreldis.2011.05.013
DO - 10.1016/j.parkreldis.2011.05.013
M3 - Article
C2 - 21665514
AN - SCOPUS:80052377889
SN - 1353-8020
VL - 17
SP - 599
EP - 605
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 8
ER -