TY - JOUR
T1 - Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease
AU - Sun, Yu
AU - Wang, Yafei
AU - Lu, Jiaming
AU - Liu, Rengyuan
AU - Schwarz, Christopher G.
AU - Zhao, Hui
AU - Zhang, Yue
AU - Xu, Lingyi
AU - Zhu, Bin
AU - Zhang, Bing
AU - Liu, Bing
AU - Wan, Suiren
AU - Xu, Yun
N1 - Publisher Copyright:
© Sun et al.
PY - 2017
Y1 - 2017
N2 - Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer's disease (AD group, n=27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy=100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD.
AB - Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer's disease (AD group, n=27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy=100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD.
KW - AD
KW - Functional connectivity
KW - MCI
KW - Parahippocampal cortex
KW - Perirhinal cortex
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U2 - 10.18632/oncotarget.17944
DO - 10.18632/oncotarget.17944
M3 - Article
C2 - 29228757
AN - SCOPUS:85035044027
SN - 1949-2553
VL - 8
SP - 99112
EP - 99124
JO - Oncotarget
JF - Oncotarget
IS - 58
ER -