Disorders of Iron Overload

Antonello Pietrangelo; Michael Torbenson

doi:10.1016/B978-0-7020-8228-3.00004-1

Disorders of Iron Overload

Antonello Pietrangelo, Michael Torbenson

Laboratory Medicine and Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Iron disorders of the liver are best understood in the context of normal iron metabolism, so the biology of iron metabolism and homeostasis is reviewed. Mutations that lead to dysregulation of normal iron homeostasis are the basis for genetic iron overload. These mutations and their clinical and histological manifestations are examined, with a focus on information relevant to diagnostic surgical pathology. Secondary iron is also discussed, including its many causes and the histological manifestations.

Original language	English (US)
Title of host publication	MacSween's Pathology of the Liver, Eighth Edition
Publisher	Elsevier
Pages	295-329
Number of pages	35
ISBN (Electronic)	9780702082283
ISBN (Print)	9780702082290
DOIs	https://doi.org/10.1016/B978-0-7020-8228-3.00004-1
State	Published - Jan 1 2023

Keywords

HFE
ferritin
ferroportin
hepcidin; genetic haemochromatosis
iron
neonatal haemochromatosis
secondary iron overload

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-7020-8228-3.00004-1

Cite this

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keywords = "HFE, ferritin, ferroportin, hepcidin; genetic haemochromatosis, iron, neonatal haemochromatosis, secondary iron overload",

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AU - Torbenson, Michael

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AB - Iron disorders of the liver are best understood in the context of normal iron metabolism, so the biology of iron metabolism and homeostasis is reviewed. Mutations that lead to dysregulation of normal iron homeostasis are the basis for genetic iron overload. These mutations and their clinical and histological manifestations are examined, with a focus on information relevant to diagnostic surgical pathology. Secondary iron is also discussed, including its many causes and the histological manifestations.

KW - HFE

KW - ferritin

KW - ferroportin

KW - hepcidin; genetic haemochromatosis

KW - iron

KW - neonatal haemochromatosis

KW - secondary iron overload

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EP - 329

BT - MacSween's Pathology of the Liver, Eighth Edition

PB - Elsevier

ER -

Disorders of Iron Overload

Abstract

Keywords

ASJC Scopus subject areas

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