TY - JOUR
T1 - "Diminished" association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample
AU - Shinozaki, Gen
AU - Kumar, Yingying
AU - Rosen, Brooke H.
AU - Rundeli, James R.
AU - Mrazek, David A.
AU - Kung, Simon
PY - 2013/10
Y1 - 2013/10
N2 - Background: The role of the promoter polymorphism (51-ITTLPR) of the serotonin transporter gene (SLC6A4) in psychiatric illnesses has been studied extensively. Serotonergic function also regulates many central nervous system, including appetite and feeding behaviors. The 5HEFLPR short allele was found to be associated with increased body mass index and obesity risk among the general population. No data is available to support generalizability of such association among psychiatric population. Methods: We examined the relationship between BMI and the 5HEFLPR genotype in a large sample of 1831 psychiatric patients at Mayo Clinic, Rochester, Minnesota, using a retrospective chart review. Results: Average BMI among groups with the short!short (2829 - 727 kgm2), the shortlong (2807 - 645 kgm2) and the longlong (2815 - 751 kgm2) genotypes of 5HEFLPR were not statistically different. This negative association persisted even with the sub-analysis of the Caucasians. However, we observed an increased rate of obesity among our psychiatric patient sample compared to the general population of Minnesota (366% versus 276%, p=0000l for males, 303% versus 244%, p=00001 for females). Also, sub-analysis showed female inpatients to have a significantly higher average BMI than outpatients (2864- 808 kgm2 versus 2713 - 692 kgm2, p=0026). This confirmed a significant association between mental health disorder and BMI. Limitations: Retrospective study design with limited control for potential confounders. Conclusions: In this large sample of psychiatric patients we found no significant association between 5HEFLPR genotype and BMI, which is different from the case with general population reported in the literature.
AB - Background: The role of the promoter polymorphism (51-ITTLPR) of the serotonin transporter gene (SLC6A4) in psychiatric illnesses has been studied extensively. Serotonergic function also regulates many central nervous system, including appetite and feeding behaviors. The 5HEFLPR short allele was found to be associated with increased body mass index and obesity risk among the general population. No data is available to support generalizability of such association among psychiatric population. Methods: We examined the relationship between BMI and the 5HEFLPR genotype in a large sample of 1831 psychiatric patients at Mayo Clinic, Rochester, Minnesota, using a retrospective chart review. Results: Average BMI among groups with the short!short (2829 - 727 kgm2), the shortlong (2807 - 645 kgm2) and the longlong (2815 - 751 kgm2) genotypes of 5HEFLPR were not statistically different. This negative association persisted even with the sub-analysis of the Caucasians. However, we observed an increased rate of obesity among our psychiatric patient sample compared to the general population of Minnesota (366% versus 276%, p=0000l for males, 303% versus 244%, p=00001 for females). Also, sub-analysis showed female inpatients to have a significantly higher average BMI than outpatients (2864- 808 kgm2 versus 2713 - 692 kgm2, p=0026). This confirmed a significant association between mental health disorder and BMI. Limitations: Retrospective study design with limited control for potential confounders. Conclusions: In this large sample of psychiatric patients we found no significant association between 5HEFLPR genotype and BMI, which is different from the case with general population reported in the literature.
KW - 5HTTLPR
KW - Body mass index
KW - Psychiatric patient
KW - SLC6A4
KW - Serotonin transporter gene
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U2 - 10.1016/j.jad.2013.06.021
DO - 10.1016/j.jad.2013.06.021
M3 - Article
C2 - 23838390
AN - SCOPUS:84888644724
SN - 0165-0327
VL - 151
SP - 397
EP - 400
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1
ER -