TY - JOUR
T1 - Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients—Neuroradiological Review Within the MRI-GENIE Study
AU - the Stroke Genetics Network (SiGN) the MRI-Genetics Interface Exploration (MRI-GENIE) Study
AU - Drake, Mattias
AU - Frid, Petrea
AU - Hansen, Björn M.
AU - Wu, Ona
AU - Giese, Anne Katrin
AU - Schirmer, Markus D.
AU - Donahue, Kathleen
AU - Cloonan, Lisa
AU - Irie, Robert E.
AU - Bouts, Mark J.R.J.
AU - McIntosh, Elissa C.
AU - Mocking, Steven J.T.
AU - Dalca, Adrian V.
AU - Sridharan, Ramesh
AU - Xu, Huichun
AU - Giralt-Steinhauer, Eva
AU - Holmegaard, Lukas
AU - Jood, Katarina
AU - Roquer, Jaume
AU - Cole, John W.
AU - McArdle, Patrick F.
AU - Broderick, Joseph P.
AU - Jiménez-Conde, Jordi
AU - Jern, Christina
AU - Kissela, Brett M.
AU - Kleindorfer, Dawn O.
AU - Lemmens, Robin
AU - Meschia, James F.
AU - Rundek, Tatjana
AU - Sacco, Ralph L.
AU - Schmidt, Reinhold
AU - Sharma, Pankaj
AU - Slowik, Agnieszka
AU - Thijs, Vincent
AU - Woo, Daniel
AU - Worrall, Bradford B.
AU - Kittner, Steven J.
AU - Mitchell, Braxton D.
AU - Rosand, Jonathan
AU - Golland, Polina
AU - Lindgren, Arne
AU - Rost, Natalia S.
AU - Wassélius, Johan
N1 - Publisher Copyright:
© Copyright © 2020 Drake, Frid, Hansen, Wu, Giese, Schirmer, Donahue, Cloonan, Irie, Bouts, McIntosh, Mocking, Dalca, Sridharan, Xu, Giralt-Steinhauer, Holmegaard, Jood, Roquer, Cole, McArdle, Broderick, Jiménez-Conde, Jern, Kissela, Kleindorfer, Lemmens, Meschia, Rundek, Sacco, Schmidt, Sharma, Slowik, Thijs, Woo, Worrall, Kittner, Mitchell, Rosand, Golland, Lindgren, Rost and Wassélius.
PY - 2020/6/25
Y1 - 2020/6/25
N2 - Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work. Methods: The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N = 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics. Results: In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P = 0.013 for χ2 test). Conclusions: This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.
AB - Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work. Methods: The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N = 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics. Results: In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P = 0.013 for χ2 test). Conclusions: This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.
KW - DWI
KW - MRI
KW - imaging
KW - phenotype
KW - stroke
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UR - http://www.scopus.com/inward/citedby.url?scp=85087703384&partnerID=8YFLogxK
U2 - 10.3389/fneur.2020.00577
DO - 10.3389/fneur.2020.00577
M3 - Article
AN - SCOPUS:85087703384
SN - 1664-2295
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 577
ER -