Diffuse panbronchiolitis

Venerino Poletti, Marco Chilosi, Gianluca Casoni, Thomas V. Colby

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease, largely restricted to Japan, that is characterized by progressive suppurative and obstructive airway disease, which, if left untreated, progresses to bronchiectasis, respiratory failure, and death. The lesion was first described in the early 1960s. In 1969 the name diffuse panbronchiolitis (DPB) was proposed to distinguish it from chronic bronchitis. Diffuse refers to the distribution of the lesions throughout both lungs, and pan refers to the involvement of inflammation in all layers of the respiratory bronchioles. Its distinctive imaging and histologic features, the coexisting sinusitis, and the isolation of Haemophilus influenzae and Pseudomonas aeruginosa in the sputum should enhance disease recognition. Neutrophils and T-lymphocytes, particularly CD8+ cells, together with cytokines IL-8 and macrophage inflammatory protein-1 are believed to play key roles in the development of this disease. Significant improvement in the prognosis of this potentially fatal disease has been reported after the use of long-term therapy with macrolide antibiotics, the effect of which is attributed to an anti-inflammatory and immunoregulatory action.

Original languageEnglish (US)
Pages (from-to)94-104
Number of pages11
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Issue number2
StatePublished - Jun 2004


  • Diffuse panbronchiolitis
  • Erythromycin
  • Foamy Macrophages
  • HLA haplotype
  • Macrolides

ASJC Scopus subject areas

  • Internal Medicine
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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