Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs

Valeria Tosello, Kunle Odunsi, Naira E. Souleimanian, Shashikant Lele, Protul Shrikant, Lloyd J. Old, Danila Valmori, Maha Ayyoub

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Natural Tregs play an essential role in controlling self-tolerance but the in vivo sites of Treg-mediated suppression remain controversial. We have previously reported the identification of distinct naïve and memory Treg populations in human circulating lymphocytes. Here we show that memory Tregs contain high proportions of inflammatory chemokine-expressing cells and comprise two populations that differ in the expression of the lymphoid chemokine receptor CCR7 and represent the counterparts of conventional CCR7+ central memory (CM) and CCR7- effector memory (EM) T cells. CM and EM Tregs exert comparable ex vivo suppressor functions but the EM population is more prominent among Tregs as compared to conventional CD4+ T cells, and is the main Treg subset found in ovarian tumors. Our data suggest that a division of labor between CM and EM Tregs ensures tolerance at lymphoid and peripheral locations including tumor sites.

Original languageEnglish (US)
Pages (from-to)291-302
Number of pages12
JournalClinical Immunology
Issue number3
StatePublished - Mar 2008


  • Immune regulation
  • Regulatory T cells
  • T cell homing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs'. Together they form a unique fingerprint.

Cite this