Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kia Teng Lim; Kia Hui Lim; Xuan Zhou; Juan Yang; Kyung Min Shin; Arya B. Mohabbat; Wyatt W. Baude; Sanjeev Nanda; David Bauer; Monique Theberath; Nicole Theberath; Brent A. Bauer; Ravindra Ganesh

doi:10.1142/S0192415X22500495

Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kia Teng Lim, Kia Hui Lim, Xuan Zhou, Juan Yang, Kyung Min Shin, Arya B. Mohabbat, Wyatt W. Baude, Sanjeev Nanda, David Bauer, Monique Theberath, Nicole Theberath, Brent A. Bauer, Ravindra Ganesh

General Internal Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Pain is the most frequently encountered symptom by patients with fibromyalgia (FM). Dietary supplements (DSs) in particular have a proven impact as a possible adjunctive therapy for symptom management in FM. However, there is currently no conclusive review outlining the evidence for DSs in pain management in FM. This study aims to assess currently available studies evaluating the use of DSs for pain relief in FM. Randomized controlled trials regarding the use of DSs on adult FM patients were included for evidence synthesis. Study results indicated that DSs significantly relieved pain in FM (SMD 1.23; 95% CI 0.02-2.43, P = 0.046) but did not improve quality of life (QoL) (SMD 0.73; 95% CI-0.07-1.53, P = 0.075) in the data. Adverse events of DSs varied from mild to severe, with the most common being gastrointestinal symptoms and androgenic side effects in 5.7% and 3.9% of patients, respectively. More well-designed RCTs are required in the future. The protocol for this review has been published on PROSPERO (CRD42020149941).

Original language	English (US)
Pages (from-to)	1197-1218
Number of pages	22
Journal	American Journal of Chinese Medicine
Volume	50
Issue number	5
DOIs	https://doi.org/10.1142/S0192415X22500495
State	Published - May 31 2022

Keywords

Clinical Trials
Dietary Supplements
Fibromyalgia
Herbal Medicine
Meta-Analysis
Pain Relief
Review

ASJC Scopus subject areas

Complementary and alternative medicine

Access to Document

10.1142/S0192415X22500495

Cite this

Lim, K. T., Lim, K. H., Zhou, X., Yang, J., Shin, K. M., Mohabbat, A. B., Baude, W. W., Nanda, S., Bauer, D., Theberath, M., Theberath, N., Bauer, B. A., & Ganesh, R. (2022). Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. American Journal of Chinese Medicine, 50(5), 1197-1218. https://doi.org/10.1142/S0192415X22500495

Lim, KT, Lim, KH, Zhou, X, Yang, J, Shin, KM, Mohabbat, AB, Baude, WW, Nanda, S, Bauer, D, Theberath, M, Theberath, N, Bauer, BA & Ganesh, R 2022, 'Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials', American Journal of Chinese Medicine, vol. 50, no. 5, pp. 1197-1218. https://doi.org/10.1142/S0192415X22500495

@article{e4f1060035d647ab9c198af7f58b3f8d,

title = "Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",

abstract = "Pain is the most frequently encountered symptom by patients with fibromyalgia (FM). Dietary supplements (DSs) in particular have a proven impact as a possible adjunctive therapy for symptom management in FM. However, there is currently no conclusive review outlining the evidence for DSs in pain management in FM. This study aims to assess currently available studies evaluating the use of DSs for pain relief in FM. Randomized controlled trials regarding the use of DSs on adult FM patients were included for evidence synthesis. Study results indicated that DSs significantly relieved pain in FM (SMD 1.23; 95% CI 0.02-2.43, P = 0.046) but did not improve quality of life (QoL) (SMD 0.73; 95% CI-0.07-1.53, P = 0.075) in the data. Adverse events of DSs varied from mild to severe, with the most common being gastrointestinal symptoms and androgenic side effects in 5.7% and 3.9% of patients, respectively. More well-designed RCTs are required in the future. The protocol for this review has been published on PROSPERO (CRD42020149941).",

keywords = "Clinical Trials, Dietary Supplements, Fibromyalgia, Herbal Medicine, Meta-Analysis, Pain Relief, Review",

author = "Lim, {Kia Teng} and Lim, {Kia Hui} and Xuan Zhou and Juan Yang and Shin, {Kyung Min} and Mohabbat, {Arya B.} and Baude, {Wyatt W.} and Sanjeev Nanda and David Bauer and Monique Theberath and Nicole Theberath and Bauer, {Brent A.} and Ravindra Ganesh",

note = "Publisher Copyright: {\textcopyright} 2022 World Scientific Publishing Company.",

year = "2022",

month = may,

day = "31",

doi = "10.1142/S0192415X22500495",

language = "English (US)",

volume = "50",

pages = "1197--1218",

journal = "American Journal of Chinese Medicine",

issn = "0192-415X",

publisher = "World Scientific Publishing Co. Pte Ltd",

number = "5",

}

TY - JOUR

T1 - Dietary Supplements for Pain Relief in Patients with Fibromyalgia

T2 - A Systematic Review and Meta-Analysis of Randomized Controlled Trials

AU - Lim, Kia Teng

AU - Lim, Kia Hui

AU - Zhou, Xuan

AU - Yang, Juan

AU - Shin, Kyung Min

AU - Mohabbat, Arya B.

AU - Baude, Wyatt W.

AU - Nanda, Sanjeev

AU - Bauer, David

AU - Theberath, Monique

AU - Theberath, Nicole

AU - Bauer, Brent A.

AU - Ganesh, Ravindra

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Pain is the most frequently encountered symptom by patients with fibromyalgia (FM). Dietary supplements (DSs) in particular have a proven impact as a possible adjunctive therapy for symptom management in FM. However, there is currently no conclusive review outlining the evidence for DSs in pain management in FM. This study aims to assess currently available studies evaluating the use of DSs for pain relief in FM. Randomized controlled trials regarding the use of DSs on adult FM patients were included for evidence synthesis. Study results indicated that DSs significantly relieved pain in FM (SMD 1.23; 95% CI 0.02-2.43, P = 0.046) but did not improve quality of life (QoL) (SMD 0.73; 95% CI-0.07-1.53, P = 0.075) in the data. Adverse events of DSs varied from mild to severe, with the most common being gastrointestinal symptoms and androgenic side effects in 5.7% and 3.9% of patients, respectively. More well-designed RCTs are required in the future. The protocol for this review has been published on PROSPERO (CRD42020149941).

AB - Pain is the most frequently encountered symptom by patients with fibromyalgia (FM). Dietary supplements (DSs) in particular have a proven impact as a possible adjunctive therapy for symptom management in FM. However, there is currently no conclusive review outlining the evidence for DSs in pain management in FM. This study aims to assess currently available studies evaluating the use of DSs for pain relief in FM. Randomized controlled trials regarding the use of DSs on adult FM patients were included for evidence synthesis. Study results indicated that DSs significantly relieved pain in FM (SMD 1.23; 95% CI 0.02-2.43, P = 0.046) but did not improve quality of life (QoL) (SMD 0.73; 95% CI-0.07-1.53, P = 0.075) in the data. Adverse events of DSs varied from mild to severe, with the most common being gastrointestinal symptoms and androgenic side effects in 5.7% and 3.9% of patients, respectively. More well-designed RCTs are required in the future. The protocol for this review has been published on PROSPERO (CRD42020149941).

KW - Clinical Trials

KW - Dietary Supplements

KW - Fibromyalgia

KW - Herbal Medicine

KW - Meta-Analysis

KW - Pain Relief

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=85132049319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85132049319&partnerID=8YFLogxK

U2 - 10.1142/S0192415X22500495

DO - 10.1142/S0192415X22500495

M3 - Review article

C2 - 35642461

AN - SCOPUS:85132049319

SN - 0192-415X

VL - 50

SP - 1197

EP - 1218

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

IS - 5

ER -

Dietary Supplements for Pain Relief in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this