Dietary sodium modulation of aldosterone activation and renal function during the progression of experimental heart failure

Wayne L. Miller, Daniel D. Borgeson, J. Aaron Grantham, Andreas Luchner, Margaret M. Redfield, John C. Burnett

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aims: Aldosterone activation is central to the sodium-fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the role of dietary sodium during the progression of experimental HF. Methods and results: Experimental HF was produced in a canine model by rapid right ventricular pacing which evolves from early mild HF to overt, severe HF. Dogs were fed one of three diets: (i) high sodium [250 mEq (5.8 g) per day, n =6]; (ii) standard sodium [58 mEq (1.3 g) per day, n =6]; and (iii) sodium restriction [11 mEq (0.25 g) per day, n =6]. During the 38-day study, haemodynamics, renal function, plasma renin activity (PRA), and aldosterone were measured. Changes in haemodynamics at 38 days were similar in all three groups, as were changes in renal function. Aldosterone activation was demonstrated in all three groups; however, dietary sodium restriction, in contrast to high sodium, resulted in early (10 days) activation of PRA and aldosterone. High sodium demonstrated significant suppression of aldosterone activation over the course of HF progression. Conclusions: Excessive dietary sodium restriction particularly in early stage HF results in early aldosterone activation, while normal and excess sodium intake are associated with delayed or suppressed activation. These findings warrant evaluation in humans to determine if dietary sodium manipulation, particularly during early stage HF, may have a significant impact on neuroendocrine disease progression.

Original languageEnglish (US)
Pages (from-to)144-150
Number of pages7
JournalEuropean Journal of Heart Failure
Issue number2
StatePublished - Feb 1 2015


  • Aldosterone
  • Canine Model
  • Dietary sodium
  • Heart failure
  • Renal function
  • Renin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Dietary sodium modulation of aldosterone activation and renal function during the progression of experimental heart failure'. Together they form a unique fingerprint.

Cite this