Diagnostic Work-Up of GERD

Marcelo F. Vela

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Gastroesophageal reflux disease (GERD) is frequently diagnosed by symptoms and good response to acid suppression with proton pump inhibitors. Further work up is required when the diagnosis of GERD is uncertain, for alarm symptoms, PPI-refractoriness, and often for extraesophageal presentations. Useful tools include endoscopy for mucosal assessment and reflux monitoring (pH or impedance-pH) to quantify reflux burden. Objective documentation of pathological reflux is mandatory prior to anti-reflux surgery. In some patients, symptoms that can be attributed to GERD may have other causes; in these patients, testing that excludes GERD helps direct the diagnostic and treatment efforts to other causes.

Original languageEnglish (US)
Pages (from-to)655-666
Number of pages12
JournalGastrointestinal Endoscopy Clinics of North America
Issue number4
StatePublished - Oct 1 2014


  • Endoscopy
  • Gastroesophageal reflux disease (GERD)
  • Heartburn
  • Impedance-pH monitoring
  • PH monitoring
  • Proton pump inhibitor test

ASJC Scopus subject areas

  • Gastroenterology


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