Diagnostic meta-analysis: Case study in gastroenterology

Bashar J. Qumseya, Michael Wallace

Research output: Chapter in Book/Report/Conference proceedingChapter


Meta-analysis refers to the use of statistical tools to combine and compare the results of multiple studies on particular outcomes on interest. Use of meta-analysis in the medical literature, including the field of gastroenterology, has been increasing. Conducting high-quality meta-analysis can be challenging. Similarly understanding published meta-analyses can be difficult. In this chapter, we will present several case studies on meta-analyses in gastroenterology. We will use these studies to shed light on several key factors in meta-analyses. These factors include the importance of choosing the appropriate inclusion and exclusion criteria, deciding on the best meta-meter of interest, recognizing and dealing with duplicate cohorts, and using direct and indirect comparisons. Our goal is to show how meta-analyses can be great tools for providing evidence-based results that can have a significant impact on clinical practice in the field of gastroenterology.

Original languageEnglish (US)
Title of host publicationDiagnostic Meta-Analysis
Subtitle of host publicationA Useful Tool for Clinical Decision-Making
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783319789668
ISBN (Print)9783319789651
StatePublished - Jan 1 2018


  • Clinical research
  • Endoscopy
  • Epidemiology
  • Gastroenterology
  • Meta-analysis
  • Systematic review

ASJC Scopus subject areas

  • General Medicine
  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology
  • General Psychology


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