Diagnostic criteria for multiple sclerosis: 2005 Revisions to the "McDonald Criteria"

Chris H. Polman, Stephen C. Reingold, Gilles Edan, Massimo Filippi, Hans Peter Hartung, Ludwig Kappos, Fred D. Lublin, Luanne M. Metz, Henry F. McFarland, Paul W. O'Connor, Magnhild Sandberg-Wollheim, Alan J. Thompson, Brian G. Weinshenker, Jerry S. Wolinsky

Research output: Contribution to journalReview articlepeer-review

4121 Scopus citations


New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity.

Original languageEnglish (US)
Pages (from-to)840-846
Number of pages7
JournalAnnals of neurology
Issue number6
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Diagnostic criteria for multiple sclerosis: 2005 Revisions to the "McDonald Criteria"'. Together they form a unique fingerprint.

Cite this