Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Cristina Di Stefano, Giulia Bruno, Maria C. Arciniegas Calle, Gayatri A. Acharya, Lynn M. Fussner, Patompong Ungprasert, Leslie T. Cooper, Lori A. Blauwet, Jay H. Ryu, Patricia A. Pellikka, Eva M. Carmona Porquera, Hector R. Villarraga

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Sarcoidosis is a systemic granulomatous disease that may affect the myocardium. This study evaluated the diagnostic and prognostic value of 2-dimensional speckle tracking echocardiography in cardiac sarcoidosis (CS). Methods: Eighty-three patients with extracardiac, biopsy-proven sarcoidosis and definite/probable diagnosis of cardiac involvement diagnosed from January 2005 through December 2016 were included. Strain parameters in early stages of CS, in a subgroup of 23 CS patients with left ventricular ejection fraction (LVEF) within normal limits (LVEF> 52% for men: > 54% for women, mean value: 57.3% ± 3.8%) and no wall motion abnormalities was compared with 97 controls (1:4) without cardiac disease. LV and right ventricular (RV) global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain and strain rate (SR) analyses were performed with TomTec software and correlated with cardiac outcomes (including heart failure and arrhythmias). This study was approved by the Mayo Clinic Institutional Review Board, and all patients gave informed written consent to participate. Results: Mean age of CS patients was 53.6 ± 10.8 years, and 34.9% were women. Mean LVEF was 43.2% ± 12.4%; LV GLS, - 12.4% ± 3.7%; LV GCS, - 17.1% ± 6.5%; LV GRS, 29.3% ± 12.8%; and RV wall GLS, 14.6% ± 6.3%. In the 23 patients with early stage CS with normal LVEF and RV systolic function, strain parameters were significantly reduced when compared with controls (respectively: LV GLS, - 15.9% ± 2.5% vs - 18.2% ± 2.7% [P =.001]; RV GLS, - 16.9% ± 4.5% vs - 24.1% ± 4.0% [P <.001]). A LV GLS value of - 16.3% provided 82.2% sensitivity and 81.2% specificity for the diagnosis of CS (AUC 0.91), while a RV value of - 19.9% provided 88.1% sensitivity and 86.7% specificity (AUC 0.93). Hospital admission and heart failure significantly correlated to impaired LV GLS (> - 14%). Conclusion: Reduced strain values in the LV GLS and RV GLS can be used in the diagnostic algorithm in patients with suspicion of cardiac sarcoidosis. These values also correlate with adverse cardiovascular events.

Original languageEnglish (US)
Article number21
JournalBMC cardiovascular disorders
Issue number1
StatePublished - Jan 20 2020


  • Cardiac sarcoidosis
  • Echocardiography
  • Speckle tracking
  • Strain

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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