Diagnosis of metastatic neoplasms: An immunohistochemical approach

Murli Krishna

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Context:-It is important to determine the type and/or site of origin of metastatic tumors for optimal clinical management. Objective:-To summarize the use of currently available immunohistochemical markers in the evaluation of metastatic tumors. Data Sources:-Review of relevant literature on immunohistochemical evaluation of tumors and the author's personal experience. Conclusions:-Immunohistochemistry is an important ancillary technique for evaluation of metastatic tumors and should be used in the context of routine morphology and clinical information. While a single marker may be used to support a known or suspected site of origin, a carefully constructed panel is strongly recommended, particularly for tumors of morphologically uncertain lineage or origin.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalArchives of Pathology and Laboratory Medicine
Issue number2
StatePublished - Feb 1 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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