Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis)

Morie A. Gertz, Robert A. Kyle

Research output: Chapter in Book/Report/Conference proceedingChapter


Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1]. The clinical presentation of amyloidosis varies greatly depending on the protein subunit of the amyloid fibril and the organs in which fibril deposition occurs [2]. Amyloidosis is classified on the basis of the structural subunit of the amyloid fibril protein.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Number of pages22
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
StatePublished - Nov 1 2013


  • Amyloidosis
  • Bortezomib
  • Cardiac biomarkers
  • Congo red
  • Dexamethasone
  • Fat aspiration
  • Heart failure
  • Hepatomegaly
  • Immunoglobulin light chain
  • Lenalidomide
  • Melphalan
  • Monoclonal gammopathy
  • Multiple myeloma
  • Nephrotic syndrome
  • Peripheral neuropathy
  • Restrictive cardiomyopathy
  • Stem cell transplant
  • Thalidomide

ASJC Scopus subject areas

  • General Medicine


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