Diagnosis and Management of Anaplastic Thyroid Cancer

Ashish V. Chintakuntlawar, Robert L. Foote, Jan L. Kasperbauer, Keith C. Bible

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Anaplastic thyroid cancer (ATC) is a devastating and usually incurable diagnosis. Clinical and pathologic diagnosis is best assessed at a tertiary center with concentrated ATC expertise. Expeditious multidisciplinary management is recommended for optimal patient outcomes. Based on multiinstitutional and population-based studies, multimodal therapy that includes chemoradiotherapy with surgery (when feasible) is the preferred initial treatment because it is associated with incrementally improved overall survival. In ATC that carries a BRAF V600E somatic mutation, combination therapy with BRAF and MEK inhibitors has shown promise but needs further study. Immunotherapeutic agents in neoadjuvant and metastatic settings are being investigated.

Original languageEnglish (US)
Pages (from-to)269-284
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
StatePublished - Mar 2019


  • Anaplastic thyroid cancer
  • Chemoradiotherapy
  • Multimodality therapy
  • Systemic therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Diagnosis and Management of Anaplastic Thyroid Cancer'. Together they form a unique fingerprint.

Cite this