TY - JOUR
T1 - Diabetes insipidus related to sedation in the intensive care unit
T2 - A review of the literature
AU - Kraus, Molly B.
AU - Leuzinger, Kahlin
AU - Reynolds, Emily
AU - Gallo de Moraes, Alice
AU - Smith, Julianna
AU - Sharpe, Emily E.
AU - Quillen, Jaxon
AU - Kosiorek, Heidi
AU - Harbell, Monica W.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/6
Y1 - 2023/6
N2 - Purpose: To identify cases of diabetes insipidus (DI) related to sedation in the ICU to determine which medications pose the greatest risk and understand patterns of presentation. Materials and methods: We searched PubMed, Embase, Scopus, Google Scholar, and Web of Science. Search terms included “polyuria,” “diabetes insipidus,” “hypnotics and sedatives,” “sedation,” as well as individual medications. Case reports or series involving DI or polyuria related to sedation in the ICU were identified. Results: We identified 21 cases of diabetes insipidus or polyuria in the ICU attributed to a sedative. Dexmedetomidine was implicated in 42.9% of cases, followed by sevoflurane (33.3%) and ketamine (23.8%). Sevoflurane was implicated in all 7 cases in which it was used (100%; 95% CI 59.0%, 100.0%), dexmedetomidine in 9 of 11 cases (81.8%; 95% CI 48.2, 97.7), and ketamine in 5 of 9 cases (55.6%; 95% CI 21.2%, 86.3%). Conclusions: Awareness of the potential for sedatives to cause DI may lead to greater identification with swifter medication discontinuation and subsequent resolution of DI.
AB - Purpose: To identify cases of diabetes insipidus (DI) related to sedation in the ICU to determine which medications pose the greatest risk and understand patterns of presentation. Materials and methods: We searched PubMed, Embase, Scopus, Google Scholar, and Web of Science. Search terms included “polyuria,” “diabetes insipidus,” “hypnotics and sedatives,” “sedation,” as well as individual medications. Case reports or series involving DI or polyuria related to sedation in the ICU were identified. Results: We identified 21 cases of diabetes insipidus or polyuria in the ICU attributed to a sedative. Dexmedetomidine was implicated in 42.9% of cases, followed by sevoflurane (33.3%) and ketamine (23.8%). Sevoflurane was implicated in all 7 cases in which it was used (100%; 95% CI 59.0%, 100.0%), dexmedetomidine in 9 of 11 cases (81.8%; 95% CI 48.2, 97.7), and ketamine in 5 of 9 cases (55.6%; 95% CI 21.2%, 86.3%). Conclusions: Awareness of the potential for sedatives to cause DI may lead to greater identification with swifter medication discontinuation and subsequent resolution of DI.
KW - Anesthetic complication
KW - Diabetes insipidus
KW - Polyuria
KW - Sedation
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U2 - 10.1016/j.jcrc.2022.154233
DO - 10.1016/j.jcrc.2022.154233
M3 - Review article
C2 - 36738631
AN - SCOPUS:85149741423
SN - 0883-9441
VL - 75
JO - Journal of Critical Care
JF - Journal of Critical Care
M1 - 154233
ER -