Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium

Joanne W. Elena, Emily Steplowski, Kai Yu, Patricia Hartge, Geoffrey S. Tobias, Michelle J. Brotzman, Stephen J. Chanock, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, H. Bas Bueno-De-Mesquita, Kathy Helzlsouer, Eric J. Jacobs, Andrea Lacroix, Gloria Petersen, Wei Zheng, Demetrius Albanes, Naomi E. Allen, Laufey Amundadottir, Ying Bao, Heiner BoeingMarie Christine Boutron-Ruault, Julie E. Buring, J. Michael Gaziano, Edward L. Giovannucci, Eric J. Duell, Göran Hallmans, Barbara V. Howard, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Charles Kooperberg, Peter Kraft, Julie B. Mendelsohn, Dominique S. Michaud, Domenico Palli, Lawrence S. Phillips, Kim Overvad, Alpa V. Patel, Leah Sansbury, Xiao Ou Shu, Michael S. Simon, Nadia Slimani, Dimitrios Trichopoulos, Kala Visvanathan, Jarmo Virtamo, Brian M. Wolpin, Anne Zeleniuch-Jacquotte, Charles S. Fuchs, Robert N. Hoover, Myron Gross

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalCancer Causes and Control
Issue number1
StatePublished - Jan 2013


  • Cohort consortium
  • Diabetes
  • Pancreatic cancer
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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