@article{9bfc7075feac48cbb1a39ddba5cc6b06,
title = "Development of thrombocytopenia during first-line treatment and survival outcomes in newly diagnosed multiple myeloma",
abstract = "The prognostic significance of novel agent-induced thrombocytopenia in newly diagnosed multiple myeloma (MM) is unknown. We identified 665 newly diagnosed patients receiving proteasome inhibitors and/or immunomodulators with pretreatment platelet counts ≥100,000/µL. Median progression-free survival (PFS) was 1.88 years (95% CI 1.48–2.38) for patients who developed treatment-related thrombocytopenia (<100,000/µL) within sixty days of initiation of first-line therapy, compared to 2.64 years (95% CI 2.39–2.78) in patients who did not (p =.042), while median overall survival (OS) was 5.70 years (95% CI 3.02–9.00) and 8.43 years (95% CI 6.62–9.17), respectively (p =.030). Platelet count reduction >70% from pretreatment baseline was similarly predictive of inferior PFS and OS. This is the first study to demonstrate the predictive and prognostic value of treatment-related thrombocytopenia in newly diagnosed MM.",
keywords = "Multiple myeloma, prognosis, response, survival, thrombocytopenia",
author = "Mellors, {Patrick W.} and Moritz Binder and Buadi, {Francis K.} and Lacy, {Martha Q.} and Gertz, {Morie A.} and Angela Dispenzieri and Hayman, {Suzanne R.} and Prashant Kapoor and Gonsalves, {Wilson I.} and Hwa, {Yi L.} and Amie Fonder and Miriam Hobbs and Taxiarchis Kourelis and Rahma Warsame and Zeldenrust, {Steven R.} and Lust, {John A.} and Nelson Leung and Go, {Ronald S.} and Kyle, {Robert A.} and Rajkumar, {S. Vincent} and Kumar, {Shaji K.}",
note = "Funding Information: P.W.M., M.B., and S.K.K. were responsible for the study conception and design; F.K.B., M.Q.L., M.A.G., A.D., S.R.H., P.K., W.I.G., Y.L.H., A.F., M.H., T.K., R.W., S.R.Z., J.A.L., N.L., R.S.G., R.A.K., S.V.R., and S.K.K. provided care for study patients; P.W.M., M.B., and S.K.K. were involved in the collection and assembly of data; M.B. performed the statistical analysis; P.W.M. wrote the manuscript. All authors participated in data analysis and interpretation, critical appraisal of the manuscript, and provided their approval of the final manuscript. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2019",
month = oct,
day = "15",
doi = "10.1080/10428194.2019.1613536",
language = "English (US)",
volume = "60",
pages = "2960--2967",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "12",
}