Abstract
BACKGROUND Radiation-induced glioblastoma (GBM) in patients previously treated for craniopharyngioma is a rare phenomenon. To the authors’ knowledge, only seven cases have previously been documented in the literature. OBSERVATIONS Herein, the authors report a case of a patient presenting with a new diagnosis of multifocal GBM 15 years after having received adjuvant radiotherapy for a craniopharyngioma. Magnetic resonance imaging revealed an extensive enhancing infiltrative lesion in the right frontal lobe as well as two satellite lesions in the contralateral frontal lobe. Histopathology on biopsy was consistent with GBM. LESSONS Even though this case is rare, it is nevertheless important to recognize GBM as a potential side effect of radiation. Long-term follow-up in postradiation craniopharyngioma patients is crucial for early detection.
Original language | English (US) |
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Article number | CASE2377 |
Journal | Journal of Neurosurgery: Case Lessons |
Volume | 5 |
Issue number | 26 |
DOIs | |
State | Published - 2023 |
Keywords
- craniopharyngioma
- glioblastoma
- radiation therapy
ASJC Scopus subject areas
- Clinical Neurology
- Surgery