Abstract
The development of reverse genetics systems for negative-stranded RNA viruses is a rapidly evolving field that has greatly advanced the study of the many different aspects of the viral life cycle. Andes virus (ANDV) is a highly pathogenic hantavirus found in South America that causes hantavirus pulmonary syndrome but to date remains poorly characterized due to the lack of a reverse genetics system for genetic manipulation. Here, we describe the first successful minigenome system for a New World hantavirus, as well as many of the obstacles that still exist in the development of such a system.
Original language | English (US) |
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Pages (from-to) | 2227-2233 |
Number of pages | 7 |
Journal | Archives of Virology |
Volume | 157 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2012 |
ASJC Scopus subject areas
- Virology