Developing a global strategy to prevent Alzheimer's disease: Leon Thal Symposium 2010

Zaven S. Khachaturian, Ronald C. Petersen, Peter J. Snyder, Ara S. Khachaturian, Paul Aisen, Mony De Leon, Barry D. Greenberg, Walter Kukull, Paul Maruff, Reisa A. Sperling, Yaakov Stern, Jacques Touchon, Bruno Vellas, Sandrine Andrieu, Michael W. Weiner, Maria C. Carrillo, Lisa J. Bain

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The fourth Leon Thal Symposium (LTS2010) was convened in Toulouse, France, on November 3, 2010. This symposium reviewed design parameters that are necessary to develop comprehensive national databases on healthy aging. Such datasets offer the potential to serve as the foundation for a systems-approach to solve the dual public health problems of: (1) early detection of people who are at elevated risk for Alzheimer's disease, and (2) the development of interventions to delay onset of, or prevent, late-life dementia. The symposium considered three interrelated components of a National Database for Longitudinal Studies on Healthy Aging as follows: (a) a registry of healthy aging adults; (b) refined computer-based assessments for data gathering, including assessments of behavioral/memory changes associated with aging that are appropriate for broad use in nonexpert settings; and (c) high performance computing/ supercomputer-based approaches for health data modeling and mining.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Mar 2011


  • Alzheimer's disease
  • Biomarkers
  • Computational biology
  • Computerized cognitive assessment
  • Dementia
  • Genetics
  • Healthy aging
  • In silico modeling
  • Longitudinal study
  • Mild cognitive impairment
  • Presymptomatic Alzheimer's disease
  • Prevention
  • Registry

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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