Detrusor overactivity assessment using ultrasound bladder vibrometry

David P. Rosen, Douglas A. Husmann, Lance A. Mynderse, Troy F. Kelly, Azra Alizad, Mostafa Fatemi

Research output: Contribution to journalArticlepeer-review


Objective. Detrusor overactivity (DO) is a urodynamic observation characterized by fluctuations in detrusor pressure (Pdet) of the bladder. Although detecting DO is important for the management of bladder symptoms, the invasive nature of urodynamic studies (UDS) makes it a source of discomfort and morbidity for patients. Ultrasound bladder vibrometry (UBV) could provide a direct and noninvasive means of detecting DO, due to its sensitivity to changes in elasticity and load in the bladder wall. In this study, we investigated the feasibility and applying UBV toward detecting DO. Approach. UBV and urodynamic study (UDS) measurements were collected in 76 neurogenic bladder patients (23 with DO). Timestamped group velocity squared (cg2) data series were collected from UBV measurements. Concurrent Pdet data series were identically analyzed for comparison and validation. A processing approach is developed to separate transient fluctuations in the data series from the larger trend of the data and a DO index is proposed for characterizing the transient peaks observed in the data. Main Results. Applying the DO index as a classifier for DO produced sensitivities and specificities of 0.70 and 0.75 for cg2 data series and 0.70 and 0.83 for Pdet data series respectively. Significance. It was found that DO can be feasibly detected from data series of timestamped UBV measurements. Collectively, these initial results are promising, and further refinement to the UBV measurement process is likely to improve and clarify its capabilities for noninvasive detection of DO.

Original languageEnglish (US)
Article number105012
JournalPhysiological Measurement
Issue number10
StatePublished - Oct 2021


  • Bladder
  • Detrusor Overactivity
  • Lamb waves
  • Ultrasound elastography
  • Urodynamics

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Biomedical Engineering
  • Physiology (medical)


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