TY - JOUR
T1 - Detection of tissue harmonic motion induced by ultrasonic radiation force using pulse-echo ultrasound and Kalman filter
AU - Zheng, Yi
AU - Chen, Shigao
AU - Tan, Wei
AU - Kinnick, Randall
AU - Greenleaf, James F.
N1 - Funding Information:
Manuscript received April 8, 2005; accepted September 10, 2006. This work is supported in part by grant EB02640 from National Institute of Health. Y. Zheng and W. Tan are with Saint Cloud State University, St. Cloud, MN (e-mail: zheng@stcloudstate.edu). S. Chen, R. Kinnick, and J. F. Greenleaf are with the Mayo Foundation, Rochester, MN. Digital Object Identifier 10.1109/TUFFC.2007.243
PY - 2007/2
Y1 - 2007/2
N2 - A method using pulse echo ultrasound and the Kalman niter is developed for detecting submicron harmonic motion induced by ultrasonic radiation force. The method estimates the amplitude and phase of the motion at desired locations within a tissue region with high sensitivity. The harmonic motion generated by the ultrasound radiation force is expressed as extremely small oscillatory Doppler frequency shifts in the fast time (A-line) of ultrasound echoes, which are difficult to estimate. In slow time (repetitive ultrasound echoes) of the echoes, the motion also is presented as oscillatory phase shifts, from which the amplitude and phase of the harmonic motion can be estimated with the least mean squared error by Kalman niter. This technique can be used to estimate the traveling speed of a harmonic shear wave by tracking its phase changes during propagation. The shear wave propagation speed can be used to solve for the elasticity and viscosity of tissue as reported in our earlier study. Validation and in vitro experiments indicate that the method provides excellent estimations for very small (submicron) harmonic vibrations and has potential for noninvasive and quantitative stiffness measurements of tissues such as artery.
AB - A method using pulse echo ultrasound and the Kalman niter is developed for detecting submicron harmonic motion induced by ultrasonic radiation force. The method estimates the amplitude and phase of the motion at desired locations within a tissue region with high sensitivity. The harmonic motion generated by the ultrasound radiation force is expressed as extremely small oscillatory Doppler frequency shifts in the fast time (A-line) of ultrasound echoes, which are difficult to estimate. In slow time (repetitive ultrasound echoes) of the echoes, the motion also is presented as oscillatory phase shifts, from which the amplitude and phase of the harmonic motion can be estimated with the least mean squared error by Kalman niter. This technique can be used to estimate the traveling speed of a harmonic shear wave by tracking its phase changes during propagation. The shear wave propagation speed can be used to solve for the elasticity and viscosity of tissue as reported in our earlier study. Validation and in vitro experiments indicate that the method provides excellent estimations for very small (submicron) harmonic vibrations and has potential for noninvasive and quantitative stiffness measurements of tissues such as artery.
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U2 - 10.1109/TUFFC.2007.243
DO - 10.1109/TUFFC.2007.243
M3 - Article
C2 - 17328326
AN - SCOPUS:33847695832
SN - 0885-3010
VL - 54
SP - 290
EP - 299
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 2
ER -