TY - GEN
T1 - Detection of brain tumor margins using optical coherence tomography
AU - Juarez-Chambi, Ronald M.
AU - Kut, Carmen
AU - Rico-Jimenez, Jesus
AU - Campos-Delgado, Daniel U.
AU - Quinones-Hinojosa, Alfredo
AU - Li, Xingde
AU - Jo, Javier
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2018
Y1 - 2018
N2 - In brain cancer surgery, it is critical to achieve extensive resection without compromising adjacent healthy, noncancerous regions. Various technological advances have made major contributions in imaging, including intraoperative magnetic imaging (MRI) and computed tomography (CT). However, these technologies have pros and cons in providing quantitative, real-time and three-dimensional (3D) continuous guidance in brain cancer detection. Optical Coherence Tomography (OCT) is a non-invasive, label-free, cost-effective technique capable of imaging tissue in three dimensions and real time. The purpose of this study is to reliably and efficiently discriminate between non-cancer and cancerinfiltrated brain regions using OCT images. To this end, a mathematical model for quantitative evaluation known as the Blind End-Member and Abundances Extraction method (BEAE). This BEAE method is a constrained optimization technique which extracts spatial information from volumetric OCT images. Using this novel method, we are able to discriminate between cancerous and non-cancerous tissues and using logistic regression as a classifier for automatic brain tumor margin detection. Using this technique, we are able to achieve excellent performance using an extensive cross-validation of the training dataset (sensitivity 92.91% and specificity 98.15%) and again using an independent, blinded validation dataset (sensitivity 92.91% and specificity 86.36%). In summary, BEAE is well-suited to differentiate brain tissue which could support the guiding surgery process for tissue resection.
AB - In brain cancer surgery, it is critical to achieve extensive resection without compromising adjacent healthy, noncancerous regions. Various technological advances have made major contributions in imaging, including intraoperative magnetic imaging (MRI) and computed tomography (CT). However, these technologies have pros and cons in providing quantitative, real-time and three-dimensional (3D) continuous guidance in brain cancer detection. Optical Coherence Tomography (OCT) is a non-invasive, label-free, cost-effective technique capable of imaging tissue in three dimensions and real time. The purpose of this study is to reliably and efficiently discriminate between non-cancer and cancerinfiltrated brain regions using OCT images. To this end, a mathematical model for quantitative evaluation known as the Blind End-Member and Abundances Extraction method (BEAE). This BEAE method is a constrained optimization technique which extracts spatial information from volumetric OCT images. Using this novel method, we are able to discriminate between cancerous and non-cancerous tissues and using logistic regression as a classifier for automatic brain tumor margin detection. Using this technique, we are able to achieve excellent performance using an extensive cross-validation of the training dataset (sensitivity 92.91% and specificity 98.15%) and again using an independent, blinded validation dataset (sensitivity 92.91% and specificity 86.36%). In summary, BEAE is well-suited to differentiate brain tissue which could support the guiding surgery process for tissue resection.
KW - Brain Cancer
KW - Image-guided surgery
KW - Machine Learning
KW - Optical Coherence Tomography
KW - Quadratic Optimization
UR - http://www.scopus.com/inward/record.url?scp=85045644273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045644273&partnerID=8YFLogxK
U2 - 10.1117/12.2292136
DO - 10.1117/12.2292136
M3 - Conference contribution
AN - SCOPUS:85045644273
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
A2 - Tuchin, Valery V.
A2 - Tuchin, Valery V.
A2 - Fujimoto, James G.
A2 - Izatt, Joseph A.
PB - SPIE
T2 - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018
Y2 - 29 January 2018 through 31 January 2018
ER -