@article{4ad0657f055f4cf589d195c76c741ca8,
title = "Design, methods, and conduct of the optic neuritis treatment trial",
abstract = "The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.",
keywords = "Controlled clinical trial, optic neuritis, randomized trial",
author = "{The Optic Neuritis Study Group} and Cleary, {Patricia A.} and Beck, {Roy W.} and Anderson, {Malcolm M.} and Kenny, {David J.} and Backlund, {Jye Yu} and Gilbert, {Peter R.} and R. Beck and Sellers, {B. J.} and P. Cleary and Backlund, {J. C.} and D. Kenny and N. Loring and S. Campbell and P. Gilbert and W. Watson and J. Zablotny and J. Keltner and C. Johnson and J. Spurr and L. Shapiro and R. Murtagh and J. Arrington and C. Atwell and M. Brodsky and B. Lyon and S. Nazarian and W. Jay and A. Luther and R. Ford and J. McCrary and B. Slight and R. Gross and L. Rolak and P. Frady and B. Katz and N. Hawker and O. Paul and M. Swenson and N. Loey and N. Kelly and E. Buckley and M. Anderson and G. Valentine and S. Pollock and W. Massey and L. Duncan and K. Kossover and L. Griffin and B. Grimson and N. Tripoli",
note = "Funding Information: The ONTT was an investigator-initiated, multicenter, randomized controlled clinical trial supported by cooperative agreements and grants from the National Eye Institute (NEI). A detailed description of the baseline characteristics of the patient group and the 6-month results of the treatment trial have been published elsewhere \[2,3\].",
year = "1993",
month = jan,
day = "1",
doi = "10.1016/0197-2456(93)90015-6",
language = "English (US)",
volume = "14",
pages = "123--142",
journal = "Controlled Clinical Trials",
issn = "0197-2456",
publisher = "Elsevier BV",
number = "2",
}