Depressive behaviour in children diagnosed with a mitochondrial disorder

E. Morava, T. Gardeitchik, T. Kozicz, L. de Boer, S. Koene, M. C. de Vries, R. McFarland, T. Roobol, R. J.T. Rodenburg, C. M. Verhaak

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.

Original languageEnglish (US)
Pages (from-to)528-533
Number of pages6
Issue number5
StatePublished - Aug 2010


  • Child behavioral checklist
  • Depression
  • Depressive behaviour
  • Mitochondrial medicine
  • Oxidative phosphorylation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology


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