Depression and intelligence in patients with Parkinson's disease and deep-brain stimulation

Courtney R. Schadt, Katie L. Cox, Michael G. Tramontana, Daniel W. Byrne, Thomas L. Davis, John Y. Fang, Peter E. Konrad, Bhavna Padaliya, Robert W. Mutter, Chandler E. Gill, Caralee R. Richardson, P. David Charles

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The goal of this study is to examine the association of depression with intelligence and education in patients with Parkinson's disease treated with bilateral subthalamic nucleus stimulation (STN-DBS). The literature has been contradictory concerning depression in Parkinson's disease patients. Some studies have shown less depression in Parkinson's disease patients with more education not treated with STN-DBS. Other recently published studies indicate that STN-DBS improves the depression associated with Parkinson's disease. No studies have examined the correlation of these factors with depression in Parkinson's disease patients treated with STN-DBS. We administered the Beck Depression Inventory (BDI) pre- and postoperatively to 21 Parkinson's disease patients (seven women, 14 men, ages 49-75) who underwent STN-DBS. The postoperative scores of the tower 50th percentile (n=8) of the Verbal Comprehensive Index of the Wechsler Adult Intelligence Scale (WAIS-III) decreased significantly (P=0.036), while the upper 50th percentile (n=13) remained nearly constant (P=0.802). Furthermore, as the education increased from high-school to graduate level, patients demonstrated less improvement in depressive symptoms postoperatively. These findings suggest that Parkinson's disease patients with lower intelligence test scores and less education benefit more with regards to depressive symptomatology after STN-DBS than patients with higher scores and education.

Original languageEnglish (US)
Pages (from-to)1121-1125
Number of pages5
JournalJournal of the National Medical Association
Issue number7
StatePublished - Jul 2006


  • Beck Depression Inventory
  • Brain
  • Depression
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)


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