Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

Eduardo E. Benarroch; Ann M. Schmeichel; Joseph E. Parisi

doi:10.1212/WNL.59.6.944

Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

Eduardo E. Benarroch, Ann M. Schmeichel, Joseph E. Parisi

Laboratory Medicine and Pathology

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61 Scopus citations

Abstract

The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 ± 2 vs 81 ± 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 ± 3 vs 47 ± 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

Original language	English (US)
Pages (from-to)	944-946
Number of pages	3
Journal	Neurology
Volume	59
Issue number	6
DOIs	https://doi.org/10.1212/WNL.59.6.944
State	Published - Sep 24 2002

ASJC Scopus subject areas

Clinical Neurology

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abstract = "The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 ± 2 vs 81 ± 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 ± 3 vs 47 ± 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.",

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N2 - The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 ± 2 vs 81 ± 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 ± 3 vs 47 ± 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

AB - The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 ± 2 vs 81 ± 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 ± 3 vs 47 ± 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

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Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

Abstract

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