Demystifying the role of mitochondria in senescence

Clara Correia-Melo; João F. Passos

doi:10.1080/23723556.2016.1162896

Demystifying the role of mitochondria in senescence

Clara Correia-Melo, João F. Passos

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.

Original language	English (US)
Article number	e1162896
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2016.1162896
State	Published - Jul 3 2016

Keywords

Ageing
mTOR
mitochondria
senescence

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2016.1162896

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title = "Demystifying the role of mitochondria in senescence",

abstract = "In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.",

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AU - Passos, João F.

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Demystifying the role of mitochondria in senescence

Abstract

Keywords

ASJC Scopus subject areas

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