Demystifying the role of mitochondria in senescence

Clara Correia-Melo, João F. Passos

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.

Original languageEnglish (US)
Article numbere1162896
JournalMolecular and Cellular Oncology
Issue number4
StatePublished - Jul 3 2016


  • Ageing
  • mTOR
  • mitochondria
  • senescence

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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