Abstract
This report concerns the demonstration and distribution of neurofibrillary tangles (NFTs), immunoreactive neuropil thread-like structures and dots in the spinal cord gray and white matter of six patients with parkinsonism-dementia complex on Guam and five patients with Guamanian amyotrophic lateral sclerosis (ALS). A monoclonal antibody to Alzheimer NFTs was used. NFTs were found in the spinal cord gray matter and white matter and all patients had immunoreactive neuropil thread-like structures and dots in the gray matter as well as in the white matter. They were particularly numerous in the lateral funiculus of patients with Guamanian ALS.
Original language | English (US) |
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Pages (from-to) | 180-184 |
Number of pages | 5 |
Journal | Acta neuropathologica |
Volume | 88 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1994 |
Keywords
- Guamanian amyotrophic lateral sclerosis
- Neurofibrillary tangle
- Neuropil thread
- Parkinsonism-dementia complex on Guam
- Spinal cord white matter
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Pathology and Forensic Medicine