Dementia with Lewy Bodies

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.

Original languageEnglish (US)
Pages (from-to)741-760
Number of pages20
JournalNeurologic clinics
Issue number3
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Clinical Neurology


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