TY - JOUR
T1 - Dementia and cerebrovascular disease
AU - Knopman, D. S.
N1 - Funding Information:
This article was supported in part by grants U01 AG 06786 ( Mayo Alzheimer's Disease Patient Registry ) and P50 AG 16574 ( Mayo Alzheimer's Disease Research Center ) from the National Institute on Aging and by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Programs of the Mayo Foundation.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - Cerebrovascular disease is an important cause of cognitive impairment and dementia in the elderly. However, there is no accepted neuropathological scheme for quantitating cerebrovascular disease in cognitive disturbances. Further, there is incomplete agreement on clinical definitions of vascular dementia. Despite these two deficiencies, many consistencies in the clinical, imaging, epidemiological, and neuropathological aspects of cerebrovascular disease and cognitive impairment have emerged. Summary points are: (1) A history of stroke, imaging evidence of stroke and neurological signs typical of stroke are the best clinical indicators of cerebrovascular disease; (2) The more clinical evidence for cerebrovascular disease implies greater cerebrovascular pathology; (3) AD is the most common accompaniment of cerebrovascular disease in dementia; (4) AD pathology can never be ruled out on clinical or imaging grounds; and (5) The more cerebrovascular pathology implies less AD pathology and vice versa for a particular level of cognitive impairment.
AB - Cerebrovascular disease is an important cause of cognitive impairment and dementia in the elderly. However, there is no accepted neuropathological scheme for quantitating cerebrovascular disease in cognitive disturbances. Further, there is incomplete agreement on clinical definitions of vascular dementia. Despite these two deficiencies, many consistencies in the clinical, imaging, epidemiological, and neuropathological aspects of cerebrovascular disease and cognitive impairment have emerged. Summary points are: (1) A history of stroke, imaging evidence of stroke and neurological signs typical of stroke are the best clinical indicators of cerebrovascular disease; (2) The more clinical evidence for cerebrovascular disease implies greater cerebrovascular pathology; (3) AD is the most common accompaniment of cerebrovascular disease in dementia; (4) AD pathology can never be ruled out on clinical or imaging grounds; and (5) The more cerebrovascular pathology implies less AD pathology and vice versa for a particular level of cognitive impairment.
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M3 - Article
AN - SCOPUS:70349161996
SN - 1284-8360
VL - 12
SP - 112
JO - Research and Practice in Alzheimer's Disease
JF - Research and Practice in Alzheimer's Disease
ER -