Delivering the message: Epimorphin and mammary epithelial morphogenesis

Derek C. Radisky; Yohei Hirai; Mina J. Bissell

doi:10.1016/S0962-8924(03)00146-6

Delivering the message: Epimorphin and mammary epithelial morphogenesis

Derek C. Radisky, Yohei Hirai, Mina J. Bissell

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.

Original language	English (US)
Pages (from-to)	426-434
Number of pages	9
Journal	Trends in Cell Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/S0962-8924(03)00146-6
State	Published - Aug 1 2003

ASJC Scopus subject areas

Cell Biology

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10.1016/S0962-8924(03)00146-6

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@article{97488d52aa05454caf7870fff0974b68,

title = "Delivering the message: Epimorphin and mammary epithelial morphogenesis",

abstract = "The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.",

author = "Radisky, {Derek C.} and Yohei Hirai and Bissell, {Mina J.}",

note = "Funding Information: Our work was supported by the US Department of Energy, Office of Biological and Environmental Research (contract DE-AC03–76SF00098) and a National Institutes of Health (grant CA57621), as well as an {\textquoteleft}Innovator{\textquoteright} grant from the US Army to M.J.B. (DAMD17-02-1-0438), an American Cancer Society fellowship to D.R., and support from the Science and Technology Agency of Japan to Y.H. We thank C. Nelson, J. Bascom, H. Liu, P. Kenny and V. Novaro for insightful discussions and editorial comments. ",

year = "2003",

month = aug,

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doi = "10.1016/S0962-8924(03)00146-6",

language = "English (US)",

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pages = "426--434",

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T1 - Delivering the message

T2 - Epimorphin and mammary epithelial morphogenesis

AU - Radisky, Derek C.

AU - Hirai, Yohei

AU - Bissell, Mina J.

N1 - Funding Information: Our work was supported by the US Department of Energy, Office of Biological and Environmental Research (contract DE-AC03–76SF00098) and a National Institutes of Health (grant CA57621), as well as an ‘Innovator’ grant from the US Army to M.J.B. (DAMD17-02-1-0438), an American Cancer Society fellowship to D.R., and support from the Science and Technology Agency of Japan to Y.H. We thank C. Nelson, J. Bascom, H. Liu, P. Kenny and V. Novaro for insightful discussions and editorial comments.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.

AB - The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.

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DO - 10.1016/S0962-8924(03)00146-6

M3 - Review article

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SN - 0962-8924

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SP - 426

EP - 434

JO - Trends in Cell Biology

JF - Trends in Cell Biology

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Delivering the message: Epimorphin and mammary epithelial morphogenesis

Abstract

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