Delayed leuko-encephalopathy in survivors with small cell lung cancer

N. K. So, B. P. O’Neill, S. Frytak, R. T. Eagan, F. Earnest, R. E. Lee

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Six patients with small cell lung cancer developed a. slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the peri-ventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

Original languageEnglish (US)
Pages (from-to)1198-1201
Number of pages4
Issue number7
StatePublished - Jul 1987

ASJC Scopus subject areas

  • Clinical Neurology


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